The CED is a theory developed in 2001 by Dr. Ethan B. Russo, MD, a board-certified neurologist, psychopharmacology researcher, and former Senior Medical Advisor to GW Pharmaceuticals. Dr. Russo believes there is an underlying endocannabinoid “tone” that reflect the levels of AEA and 2-AG. Two natural produced molecules, known as endocannabinoids. The theory proposes that sometimes the “tone” drops out of balance causing an “imbalance” or “deficiency”. This deficiency can then manifest itself in psychosomatic symptoms like migraines, anxiety, and sleeping issues. In order remedy this deficiency by bring the “tone” back in balance the use of phytocannabinoids and synthetic cannabinoids are recommended.
More on the EndoCannabinoid System (ECS)
Cannabinoids
What are Cannabinoids?
God's gift to humans and dogs.
cannabinoids
cannabidiol the "wonder molecule" was discoverd in 1942
endocannabinoids(internal) phytocannabinoid(plant) syntehetic(human-made)
113 phytocannabinoids found in the cannabis sativa plant
40% of plant extract
- 1940 cannabinol (CBN) CB2
- 1942 cannabidiol (CBD) GPCR5
- 1964 delta-9-teterahydrocannabinol (THC) CB1
empirical evidence
PubMed studies on Cannabis
- The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD
- Care and Feeding of the Endocannabinoid System : A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
- Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
PubMed studies for treatment for
Endocannabinoid (EC) System
physiologic system
centeral to health and healing of every human and most animals
regulates internal and cellular homeostasis
system consists of
- receptors
- endogenous ligands
- ligand metabolic enzymes
endocannabinod tone
2 receptor types
- CB1 - nervous system, connective tissues, gonads, glads, and organs (brain)
- CB2 - immune system (spleen) anti-imflammatory
GPCR - G Protein-coupler receptor
endocannabinoids
Molecule type:natural
anandamide (AEA)
2-arachidonoylglycerol (2-AG)
syntehetic
Molecules type: pharmacotical > pharmaceutical
dronabinol (Marinol)
nabilone (Cesanmet)
(therapeutic) (long term health issues)
physiological & mental processes
non habit-forming | no psychoactive properties
daily use | will not impair user
liquid | 3rd party tested | soil 2 oil
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