Clinical Endocannabinoid Deficiency (CED)

The CED is a theory developed in 2001 by Dr. Ethan B. Russo, MD, a board-certified neurologist, psychopharmacology researcher, and former Senior Medical Advisor to GW Pharmaceuticals. Dr. Russo believes there is an underlying endocannabinoid “tone” that reflect the levels of AEA and 2-AG. Two natural produced molecules, known as endocannabinoids. The theory proposes that sometimes the “tone” drops out of balance causing an “imbalance” or “deficiency”. This deficiency can then manifest itself in psychosomatic symptoms like migraines, anxiety, and sleeping issues. In order remedy this deficiency by bring the “tone” back in balance the use of phytocannabinoids and synthetic cannabinoids are recommended.

More on the EndoCannabinoid System (ECS)


What are Cannabinoids?

God's gift to humans and dogs.


cannabidiol the "wonder molecule" was discoverd in 1942

endocannabinoids(internal) phytocannabinoid(plant) syntehetic(human-made)

113 phytocannabinoids found in the cannabis sativa plant

40% of plant extract

empirical evidence

PubMed studies on Cannabis

PubMed studies for treatment for

Endocannabinoid (EC) System

physiologic system

centeral to health and healing of every human and most animals

regulates internal and cellular homeostasis

system consists of

  • receptors
  • endogenous ligands
  • ligand metabolic enzymes

endocannabinod tone

2 receptor types

  • CB1 - nervous system, connective tissues, gonads, glads, and organs (brain)
  • CB2 - immune system (spleen) anti-imflammatory

GPCR - G Protein-coupler receptor

Types of Cannabinoids


Molecule type:natural

anandamide (AEA)

2-arachidonoylglycerol (2-AG)


Molecule type: plant

Phytocannabinoids are plant substances that stimulate cannabinoid receptors

    top 3
  • cannabinol (CBN)
  • cannabidiol (CBD)
  • delta-9-tetrahydrocannabinol (THC)


Molecules type: pharmacotical > pharmaceutical

dronabinol (Marinol)

nabilone (Cesanmet)

(therapeutic) (long term health issues)

physiological & mental processes

non habit-forming | no psychoactive properties

daily use | will not impair user

liquid | 3rd party tested | soil 2 oil


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